To study effect of bolus high osmolarity IV fluids (colloid) on pulse, blood pressure when given before and after tourniquet release in total knee replacements.

Colloid Preloading Vs Co-loading during tourniquet deflation: An Assessment of hemodyanamic stability in Total knee replacements.

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2019/01/016838

Enrollment

Registered

2019-01-02

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: GROUP1: Patients will be given 6% starch pre-loading (5ml/kg), 30 minutes before tourniquet release.The vitals will be assessed during tourniquet release. Intervention2: Group2: Patient

Eligibility

Inclusion criteria

Inclusion criteria: 18-65 yr ASA grade I and II Elective Total knee arthroplasty patients Under Spinal anesthesia

Exclusion criteria

Exclusion criteria: Emergency surgery Long standing Diabetes cases or on insulin. Hypertensive patients on more than one antihypertensive drugs or on diuretics, or on beta blocker, or alfa2 agonists. Altered coagulation profile, or on antiplatelet drugs.

Design outcomes

Primary

Measure	Time frame
1.Impact of tourniquet release on immediate hemodynamic stability. 2. Effectiveness of pre-loading and co-loading in attenuating hemodynamic variation Timepoint: 30 minutes after tourniquet release	—

Secondary

Measure	Time frame
1.Effect of preloading on baseline vitals. 2. Effect of tourniquet inflation on hemodynamicsTimepoint: till end of surgery	—

Countries

India

Contacts

Public ContactAKHYA KUMAR KAR

NIZAMS INSTITUTE OF MEDICAL SCIENCES

karakshay@gmail.com7799895511

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026