Health Condition 1: I10- Essential (primary) hypertension
Conditions
Interventions
Intervention1: NA: NA
Intervention2: Injection Labetalol Hydrochloride: In this study, we are comparing the efficacy of two different doses of Labetalol Hydrochloride in attenuation of haemodynamic r
Sponsors
SSG Hospital
Eligibility
Inclusion criteria
Inclusion criteria: We include ASA grade II patients posted for planned surgery under general anasthesia requiring orotracheal intubation and having controlled hypertension.
Exclusion criteria
Exclusion criteria: Patients who refuse to give consent. Pregnant and lactating women. Anticipated difficult airway and obesity(BMI >35). Patient having allergy to study drug. Patient with sick sinus syndrome (including sino-atrial block),second or third degree heart block and persistent bradycardia ( Patients is having history of taking medication for any sort of illness like verapamil, diltiazem, digitalis glycosides, clonidine, monoamineoxidase inhibitors (except MOA-B inhibitors) and beta blocker. Patient with systemic diseases like cardiovascular, respiratory diseases like bronchial asthma and COPD, neurological, psychological, hepatic, untreated phaeochromocytoma,renal disease (diagnosed by clinical judgments and investigations) and on medication of above mentioned diseases. Time more than 20s or requiring more than two attempts for laryngoscopy and intubation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Both doses of Labetalol Hydrochloride are expected to attenuate hemodynamic response to laryngoscopy and intubation in dose dependent manner in controlled hypertensive patients.Timepoint: Both doses of Labetalol Hydrochloride attenuate hemodynamic response to laryngoscopy and intubation in dose dependent manner in early 20 minutes after doing airway instrumentation in controlled hypertensive patients.as this first this few minutes is very crucial causing complication like myocardial ischemia and cerebrovascular events we will observe the response for this early minutes after airway instrumentation. | — |
Secondary
| Measure | Time frame |
|---|---|
| To study the different side effect of study drugTimepoint: we will obeserve various complication like bradycardia,hypotension,any cardiac arrythmia in the patient till after the giving study drug to the complition of operative procedure. | — |
Countries
India
Contacts
Public ContactDr Komal Modi
Baroda Medical College
Outcome results
None listed