Health Condition 1: L80- Vitiligo
Conditions
Interventions
Intervention1: Recipient site preparation by dermabrasion followed by NCES
: 1. The recipient site will be shaved, cleaned with betadine and surgical spirit and anaesthetized with mixture of 2% lignoc
Sponsors
Post graduate institute of medical education and research
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with a clinical diagnosis of generalized vitiligo 2. Patients with symmetrical lesions of size > 1.5cm x 1cm present on trunk or extremities including acral areas. 3. Vitiligo lesions has been stable for 1 year. 4. Disease not responding to medical treatment, or there are residual patches (after medical therapy) of vitiligo . 5. Maximum size of vitiligo patches to be selected for surgery will not be >100cm2.
Exclusion criteria
Exclusion criteria: Age less than 18 years 2) Pregnancy and lactation 3) Patient with actively spreading vitiligo 4) History of Koebnerisation 5) History of hypertrophic scars or keloidal tendency 6) Bleeding disorders 7) Patients with unrealistic expectation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the difference in extent of repigmentation by the three different methods at 12 weeks of post treatment follow up in a given patient of stable vitiligo. Repigmentation will be assessed as follows: â?¤25% Minimal repigmentation 26-50% Mild repigmentation 51-75% Moderate repigmentation 76-90% Marked repigmentation 90% Excellent repigmentation Timepoint: To assess the difference in extent of repigmentation by the three different methods at 8 days,4 weeks, 8 weeks and 12 weeks of post treatment follow up in a given patient of stable vitiligo. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the color matching of repigmented area.Timepoint: Colour matching of repigmented skin is assessed as â??somewhat lighter thanâ??, â??same asâ?? or â??somewhat darker thanâ?? normal skin;To assess the patient satisfaction (patient global assessment) and to compare the quality of life assessement post procedure with that of pre procedure.Timepoint: Assessment done pre procedure and at 12 weeks;To assess the pattern of repigmentation attained post-procedure.Timepoint: The repigmentation pattern obtained post procedure will be noted as â??diffuseâ??, â??perifollicularâ?? or â??migrating from the bordersâ?? at 8 days,4 weeks, 8 weeks and 12 weeks.;To compare the effect of recipient site preparation on acral vs non-acral areas.Timepoint: To assess the difference in extent of repigmentation by the three different methods at 8 days,4 weeks, 8 weeks and 12 weeks of post treatment follow up in acral and non acral areas in a given patient of stable vitiligo.;To monitor adverse events if anyTimepoint: At Recipient site : infection, milia, scarring and rejection. At Donor site : infection, milia, scarring, hypopigmentation and hyperpigmentation at 8 days,4 weeks, 8 weeks and 12 weeks. | — |
Countries
India
Contacts
Public ContactDrDavinder Parsad
Post graduate institute of medical education and research
Outcome results
None listed