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Changes in eye scans of brothers and sisters of patients with conical eyes in South India

Corneal topographic changes in healthy siblings of patients with keratoconus in South India

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/12/016684
Enrollment
185
Registered
2018-12-14
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Dr Mohan Shruti Ramanujam
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion Criteria: 1. Siblings of patients diagnosed with clinical keratoconus 2. Age 6-40 years

Exclusion criteria

Exclusion criteria: Exclusion Criteria: (both patients and siblings) 1. Persons who are not willing to give an informed written consent or those for whom parents are unwilling to give written informed consent. 2. Patients who have previously undergone keratorefractive surgery since the corneal topography will be altered. 3. Patients who have previously undergone collagen cross linking. This procedure leads to warping of corneal topography and such patients will most likely already have been diagnosed with keratoconus. 4. Persons in whom performing corneal topography mapping is not possible eg: Corneal scar or those who do not cooperate or are too young to cooperate for corneal topography.

Design outcomes

Primary

MeasureTime frame
1. Corneal topographic abnormalities and patterns seen in siblings of patients with keratoconus 2. Prevalence of keratoconus and suspected keratoconus in siblings of patients with keratoconus 3. Documentation and analysis of the various expressions of keratoconus including forme fruste keratoconus.Timepoint: 1 year 6 months

Secondary

MeasureTime frame
NilTimepoint: Nil

Countries

India

Contacts

Public ContactMohan Shruti Ramanujam

Aravind Eye Hospital and Postgraduate Institute of Ophthalmology

josyfred@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026