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Role of MgSO4 in reducing dose requirement of PROPOFOL during Neurosurgical procedure.

Evaluation of effect of MgSO4 infusion in reducing Intraoperative dose requirement of PROPOFOL during elective Neurosurgery.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/12/016673
Enrollment
60
Registered
2018-12-14
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- ASA1 & ASA2

Interventions

Control Intervention1: MgSO4 & PROPOFOL: MgSO4 decreases the dose requirement of prorpofol during anaesthesia Control Intervention2: MgSO4 and placebo(NS): MgSO4 (50mg/kg loading dose and 8mg/kg maint

Sponsors

Department of anaesthesiology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: pt undergoing elective neurosurgery ASA1 and ASA2

Exclusion criteria

Exclusion criteria: allergy to mgso4 or any other study drug, pt taking any enzyme inducer or inhibitor drug, pt refusal, renal,hepatic or cardiovascular dysfunction, atrioventricular conductance disturbances, opioid or analgesic abuse, pt on chronic treatment with CCB or Magnesium.

Design outcomes

Primary

MeasureTime frame
total dose of propofol required during elective neurosurgeryTimepoint: 1,5,10,15,30,45,60,90,120 mins and at the end of surgery—

Secondary

MeasureTime frame
heart rate, SBP, DBP, MAP. SpO2, EtCO2, BIS,TOFTimepoint: 1,5,10,15,30,45,60,90,120 mins and at the end of surgery—

Countries

India

Contacts

Public ContactDr KUMAR ASHIM

IMS BHU

ldmishra@rediffmail.com9415266514

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026