A Clinical trial To compare the effect of dexmedetomidine and clonidine during laproscopic uterus removal operation under general anaesthesia.

Comparative study of effect of dexmedetomidine versus clonidine on hemodynamic stability and postoperative analgesia during laproscopic assisted vaginal hysterectomy.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/12/016609

Enrollment

100

Registered

2018-12-11

Start date

Unknown

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N80-N98- Noninflammatory disorders of female genital tract

Interventions

Intervention1: Inj.clonidine 1 mcg/kg Inj.dexmedetomidine 1 mcg/kg.: General anaesthesia will be given for laparoscopic assisted vaginal hysterectomy. Group A will receive inj.dexmedetomidine 1 mcg/kg

Eligibility

Inclusion criteria

Inclusion criteria: ASA Physical status I and II. Elective laparoscopic assisted vaginal hysterectomy.

Exclusion criteria

Exclusion criteria: ASA physical status III,IV and V. Patients with aortic stenosis. Patient with history of congestive heart failure,liver disease,renal failure. Patients with any degree of atrioventricular block. Patients taking beta blocker and monoamine-oxidase inhibitors.

Design outcomes

Primary

Measure	Time frame
To compare the outcome attenuation of hemodynamic response to pneumoperitonium and post operative analgesia during general anaesthesia in laparoscopic assisted general anaesthesiaTimepoint: Parameters like Heart rate,Systolic Blood pressure,Diastolic Blood pressure,Mean arterial Blood pressure and oxygen saturation are will be monitored at Baseline,Before induction,3 mins after Intubation,Before pneumoperitoneum,10 mins after pneumoperitoneum,then at every 30 mins interval till 180 mins.Along with this, above mentioned parameters will also be monitored 10 mins after pneumoperitoneum release and ten mins after extubation.VAS Pain Score will be monitored .	—

Measure

Time frame

To compare the outcome attenuation of hemodynamic response to pneumoperitonium and post operative analgesia during general anaesthesia in laparoscopic assisted general anaesthesiaTimepoint: Parameters like Heart rate,Systolic Blood pressure,Diastolic Blood pressure,Mean arterial Blood pressure and oxygen saturation are will be monitored at Baseline,Before induction,3 mins after Intubation,Before pneumoperitoneum,10 mins after pneumoperitoneum,then at every 30 mins interval till 180 mins.Along with this, above mentioned parameters will also be monitored 10 mins after pneumoperitoneum release and ten mins after extubation.VAS Pain Score will be monitored .

—

Secondary

Measure	Time frame
HR,SBP,DBP,MAP ,Spo2,VAS score and complications like bradycardia and hypotension are monitored.Timepoint: 5 hours	—

Countries

India

Contacts

Public ContactSETHU MADHAVA KUMAR V

Aarupadai veedu medical college and hospital.

vallijegan@gmail.com9940882722

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026