Treatment for melasma by metformin lotion

Topical metformin in the treatment of melasma: A preliminary clinical trial.

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/12/016588

Enrollment

Registered

2018-12-10

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L811- Chloasma

Interventions

Intervention1: Group 1: 20 patients will be treated with topical metformin. : â?¢Topical metformin will be prepared by mixing metformin powder with 70% alcohol and propylene glycol in 30% weight: vo

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients having melasma of more than 18 years age. 2) Patients who are not on topical medications for melasma treatment for atleast 2 weeks , 1 month for systemic steroids, 3 months for laser, dermabrasion or peels. 3) Patients who are willing to participate in the study.

Exclusion criteria

Exclusion criteria: 1)Pregnant and lactating women 2) Patients on oral contraceptives, phenytoin 3) Patients with renal dysfunction. 4) Patients who are allergic to the investigating medications. 5) Patients with acne vulgaris, rosacea.

Design outcomes

Primary

Measure	Time frame
safetyTimepoint: 8 weeks	—

Secondary

Measure	Time frame
Improvement in Melasma area and severity index scoreTimepoint: 8 weeks	—

Countries

India

Contacts

Public ContactDr Naveen Kumar A C

Hassan institute of medical sciences

dr.ravikumarbc@gmail.com9448742905

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026