Health Condition 1: J22- Unspecified acute lower respiratory infection
Conditions
Interventions
None listed
Sponsors
Public Health England
Eligibility
Inclusion criteria
Inclusion criteria: Group 1: All geneXpert positive newly diagnosed treatment naive adult patients ( >18 years of age) with pulmonary tuberculosis diagnosed at the Microbiology department Group 2: All geneXpert positive newly diagnosed treatment naive adult patients ( >18 years of age) with extra pulmonary tuberculosis diagnosed at the Microbiology department Group 3: Bacteriologically confirmed cases of Pneumonia. Group 4: Healthy volunteers who are negative for Tuberculin Skin Test or Interferon Gamma Release Assay (to rule out latent TB)
Exclusion criteria
Exclusion criteria: HIV positive Patients on steroids or other immunosuppressive drugs Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This study will determine immune cell type profiles and specific biomarker expression patterns for various cell-types in PTB and EPTB, as well as in pneumonia (positive lung infection disease control (e.g. H. influenzae and S. pneumoniae) and healthy controlsTimepoint: 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| The development of host biomarkers based TB diagnostic kits may help clinicians to screen for, diagnose and follow the progression of TB at an earlier stageTimepoint: 5 years | — |
Countries
India
Contacts
Public ContactDr Noyal Mariya Joseph
JIPMER
Outcome results
None listed