A study to compare silk fibroin and collagen membranes with graft derived from animals in treating furcation defects

Comparative Evaluation of Silk Fibroin over Collagen Membrane with Xenograft in the Treatment of Grade II Furcation Defects: A 12 Month Randomized Control Trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/12/016509

Enrollment

Registered

2018-12-03

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Silk Fibroin Membrane Combined with Xenograft : Commercially Available Xenograft, Silk Fibroin Membrane to be Manufactured Control Intervention1: Collagen Membrane Combined wit

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients within the age group of 30-50 years both males and females Patients who are willing and give informed consent Patients who maintain their oral hygiene Clinical and radiographic evidence of mandibular buccal furcation defect >= 3mm Vital teeth Presence of at least 2mm of keratinized gingiva on selected tooth Vertical probing depth

Exclusion criteria

Exclusion criteria: Known allergy to any of the material Patients on any medication Patients on antibiotic therapy within last 3 months Patients who are medically compromised or under therapeutic regimen that may alter the probability of tissue and bone healing Pregnancy and lactation Smokers Acute infections- HIV Metabolic bone diseases- osteoporosis, rheumatoid arthritis Teeth with mobility and hopeless prognosis Patients with previous periodontal regenerative therapies in the selected area 6 months prior to the study

Design outcomes

Primary

Measure	Time frame
To compare the clinical and radiological outcomes of silk fibroin and collagen membrane with xenograft in the treatment of grade II furcation defectsTimepoint: 3,6,12 MONTHS	—

Secondary

Measure	Time frame
1. To assess the effectiveness of silk fibroin and xenograft alone in management of grade II furcation. 2. To assess the effectiveness of collagen membrane and xenograft alone in the management of grade II furcation. 3. To evaluate the efficacy of silk fibroin with xenograft over collagen membranes with xenograft with regard to clinical parameters and bone fill using radiographs. Timepoint: 3,6,12 MONTHS	—

Measure

Time frame

1. To assess the effectiveness of silk fibroin and xenograft alone in management of grade II furcation. 2. To assess the effectiveness of collagen membrane and xenograft alone in the management of grade II furcation. 3. To evaluate the efficacy of silk fibroin with xenograft over collagen membranes with xenograft with regard to clinical parameters and bone fill using radiographs. Timepoint: 3,6,12 MONTHS

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Countries

India

Contacts

Public ContactArchana R Sankar

JSS Dental College and Hospital

sheelagujjari@gmail.com9448836777

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026