Health Condition 1: O149- Unspecified pre-eclampsia
Conditions
Interventions
Intervention1: Norepinephrine group: Patients will receive norepinephrine 4 microg intravenously for treatment of each episode of hypotension till the time of delivery
Control Intervention1: Phenyleph
Sponsors
University College of Medical Sciences and Guru Teg Bahadur Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Preeclamptic females with singleton pregnancy undergoing caesarean section under spinal anaesthesia 2. Preeclampsia diagnosed as BP > 140/90 mmHg on two or more occasions at least 4 hrs apart and proteinuria > 300 mg/ 24 hrs or > 1+ dipstick test
Exclusion criteria
Exclusion criteria: 1. Maternal complications other than preeclampsia e.g. chronic hypertension, other cardiovascular disease, cerebrovascular disease 2. Multiple gestation 3. Known fetal abnormality 4. Patients with absolute or relative contra-indications for spinal anaesthesia e.g. infection in lumbar area, coagulation abnormalities, platelet count 5. Severe fetal distress or other conditions requiring immediate induction of general anaesthesia 6. Patients on monoamine oxidase inhibitors or tricyclic antidepressants 7. History suggestive of mesenteric or peripheral vascular thrombosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Umbilical artery pHTimepoint: Time of delivery of baby | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. APGAR scores at 1 and 5 minutes 2. Incidence of fetal acidosis, defined as umbilical artery pH 7.20 3. Number of vasopressor boluses given 4. Number of episodes of hypotension 5. Incidence of tachycardia/bradycardia/arrhythmias/hypertension 6. Incidence of nausea, vomiting, dizziness or any other complication Timepoint: Till the time of delivery of baby | — |
Countries
India
Contacts
Public ContactDr Lakshmi R
University College of Medical Sciences and Guru Teg Bahadur Hospital
Outcome results
None listed