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Use of medication following delivery to improve the heart function in women who had high blood pressure during pregnancy

ââ?¬Å?Efficacy of Postpartum Angiotensin Converting Enzyme Inhibitor in improving cardiovascular function and reducing cardiovascular risk in women with Early onset Pre-eclampsia: A Randomized, Double-blind, Placebo-Controlled Pilot Studyââ?¬? - i-PACE Trial

Status
Recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/11/016460
Enrollment
50
Registered
2018-11-28
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O149- Unspecified pre-eclampsia

Interventions

Intervention1: Enalapril: Enalapril to be taken once daily, with or without food. (5mg per day increased by 5mg every week (One tab per week) to max dose 20 mg per day (ie max 4 tab per day)) Contr

Sponsors

JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Women with preterm Pre-eclampsia defined as those with PE according to ISSHP 2018 criteria and delivering within 37 weeksââ?¬• gestation 2. Postpartum, within 3 days of delivery 3. Able to provide informed consent

Exclusion criteria

Exclusion criteria: 1. Known cardiac disease or pre-pregnancy chronic hypertension 2. Contraindication to ACE inhibitors 3. Serum creatinine > 1.1mg/dl

Design outcomes

Primary

MeasureTime frame
Reduction in Left Ventricular(LV) Mass IndexTimepoint: 6 months post randomisation—

Secondary

MeasureTime frame
Change in biomarkers (hs-cTnT, PlGF, sFlt, NTproBNP, NOx, oxidant antioxidant ratio)Timepoint: 6 months post randomisation;Change in parameters of cardiac function ( LVEF, CO, SV, E/Eââ?¬â?¢ ratio)Timepoint: 6 months post randomisation—

Countries

India

Contacts

Public ContactAnish Keepanasseril

JIPMER, Puducherry

keepan_r@yahoo.com08903307141

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026