Health Condition 1: N939- Abnormal uterine and vaginal bleeding, unspecified Health Condition 2: D140- Benign neoplasm of middle ear, nasal cavity and accessory sinuses Health Condition 3: K412- Bilateral femoral hernia, withoutobstruction or gangrene Health Condition 4: K402- Bilateral inguinal hernia, withoutobstruction or gangrene Health Condition 5: N22- Calculus of urinary tract in diseases classified elsewhere Health Condition 6: K81- Cholecystitis Health Condition 7: H71- Cholesteatoma of
Conditions
Interventions
Control Intervention1: Fentanyl with dexmedetomidine: Fentanyl 2 mcg/kg with dexmedetomidine 1 mcg/kg diluted in 100 ml of saline over 10 mins
Control Intervention2: Fentanyl with magnesium Sulpahte:
Sponsors
Lady Hardinge Medical College And Associated Hospitals
Eligibility
Inclusion criteria
Inclusion criteria: All physical status ASA I patients undergoing general anesthesia with endotracheal intubation.
Exclusion criteria
Exclusion criteria: Any emergency surgeries Patients receiving total intravenous anaesthesia Anticipated difficult airway Repeated or multiple attempts at intubation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percent change in stress hormone levels (DHEAs and cortisol) from baseline.Timepoint: Baseline and at 2 mins after intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Percent change in stress hormone DHEAs and cortisol, heart rate, systolic blood pressure, diastolic blood pressure and mean blood pressure in the three groups from the baseline with fentanyl alone or fentanyl with either dexmedetomidine or magnesium sulphate.Timepoint: Change in hormone DHEAS and cortisol levels at baseline and 2 minutes after intubation.Heart rate,SBP,DBP and MBP at baseline, 5mins after drug given,10 mins after drug given,at the time of intubation, 2 mins after intubation,every 2 mins till 10 mins. | — |
Countries
India
Contacts
Public ContactNishant Kumar
Lady Hardinge Medical College And Associated Hospitals
Outcome results
None listed