Comparative Evaluation of Single and Multiple Times Photodynamic Therapy using Indocyanine Green as an Adjunct to Scaling and Root Planing on Gingival Crevicular Fluid MMP 8 levels in the Treatment of Chronic Periodontitis: A Split-Mouth Clinical and Biochemical Study.

Comparative Evaluation of Single and Multiple Session Photodynamic Therapy using Indocyanine Green as an Adjunct to Scaling and Root Planing on Gingival Crevicular Fluid MMP 8 levels in the Treatment of Chronic Periodontitis: A Split-Mouth Clinical and Biochemical Study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/11/016364

Enrollment

Registered

2018-11-15

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Single session of photodynamic therapy by diode laser activated indocyanine green: performed at 7 days following scaling and root planing Control Intervention1: Multiple sessions of pho

Eligibility

Inclusion criteria

Inclusion criteria: 1.Systemically healthy subjects aged between 18 to 60 years rendering informed consent to participate in the study. 2.Subjects having at least 20 natural teeth with a minimum of three teeth in each quadrant. 3.Subjects diagnosed with chronic periodontitis according to American Academy of Periodontology (AAP) classification 1999 16 with at least 30% sites examined having >3mm attachment loss with radiographic evidence of bone loss. 4.Subjects having at least one tooth per quadrant with attachment loss >=3mm and probing depth >=4 mm with corresponding tooth in contralateral quadrant in maxilla or mandible with similar site characteristics separated by atleast one tooth.

Exclusion criteria

Exclusion criteria: 1.Subjects who have received any form of surgical or non-surgical periodontal therapy within the past 6 months. 2.Subjects who have received antimicrobial and / or anti-inflammatory therapy within the past 3 months. 3.Subjects with systemic disease such as diabetes mellitus, hypertension, bleeding disorders, uremia, anticoagulants, steroids and nutritional supplements. 4.Subjects who are smokers and consume tobacco and betel nut in any form 5.Pregnant women and lactating mothers. 6.Subjects having teeth with endodontic -periodontal lesions. 7.Subjects wearing orthodontic appliances. 8.Subjects with untreated grossly carious and fractured teeth. 9.Subjects with excessive functional loading. 10.Subjects having teeth with overhanging restorations and ill-fitting prosthesis. 11.Third molars. 12.Teeth with furcation involvements will not be considered as study teeth. 13.Allergy to Indocyanine Green/Sulphur Iodide.

Design outcomes

Primary

Measure	Time frame
Outcomes to be evaluated clinical parameters of probing depth, relative clinical attachment level, gingival recession, plaque index, gingival index, sulcular bleeding index and gingival crevicular fluid MMP 8 levels.Timepoint: Baseline 6 weeks from baseline 12 weeks from baseline	—

Secondary

Measure	Time frame
Gingival crevicular fluid MMP 8 levels.Timepoint: Baseline 6 weeks from baseline 12 weeks from baseline	—

Countries

India

Contacts

Public ContactDr Vineet Kini

MGM DENTAL COLLEGE AND HOSPITAL, NAVI MUMBAI

drvinkin@gmail.com9769804390

Outcome results