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A clinical study to know the differences in the maximum response produced by the two drugs of two drugs (Atracurium and Cisatracurium) in terms of haemodynamic effects and pharmacological actions in the patients who are undergoing surgeries under General Anesthesia.

Comparison of efficacy of Atracurium versus Cisatracurium in patients undergoing surgeries under General Anaesthesia - ACA

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/11/016361
Enrollment
60
Registered
2018-11-15
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Control Intervention1: ATRACURIUM: ATRACURIUM : INTUBATION DOSE :0.5mg/kg iv MAINTENANCE DOSE :0.1mg/kg iv Control Intervention2: CISATRACURIUM: CISATRACURIUM: INTUBATION DOSE: 0.1mg/kg iv MAINTENANC

Sponsors

DrAswani Baskaran
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I ASA II ASAIII Both elective and emergency procedures

Exclusion criteria

Exclusion criteria: ASAIV Pregnant patients Patients with Bronchial asthma Patients with history of cardiovascular disorders Patients with history of hepatic and renal disorders Patients on medications known to interact with neuromuscular blocking drugs

Design outcomes

Primary

MeasureTime frame
Onset and duration of action of neuromuscular blocking drugTimepoint: Onset of action : time from the administration of drug till TOF0. Duration of action is time from administration of drug till TOF1—

Secondary

MeasureTime frame
Haemodynamic variability ( HR SBP DBP SPO2 ) Histamine release laryngoscopyTimepoint: 10min 20min 30min 45min 60min 75min 90min 105min 120min—

Countries

India

Contacts

Public ContactDrAswani Baskaran

Chettinad Hospital and Research Institute

drbala.srmc@gmail.com9940300100

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026