Health Condition 1: 4- Measurement and Monitoring
Conditions
Interventions
Control Intervention1: GCF free haem concentration and subgingival microbial composiiton is compared at periodontally healthy and diseased sites in smokers and non-smokers: GCF free haem and subgingiv
Sponsors
Rajiv Gandhi University of Health Sciences Karnataka
Eligibility
Inclusion criteria
Inclusion criteria: 1. Systemically healthy individuals aged between 20-50 years 2. Subjects with at least 20 teeth and 2 non-adjacent probing pocket depth >= 5mm and CAL >= 3mm per quadrant with radiographic bone loss >20%. 3. Current smokers i.e. persons who have smoked 100 cigarettes and who currently smoke every day or someday will be selected (smokers group)6
Exclusion criteria
Exclusion criteria: 1. Medically compromised patients or any systemic illness which can influence the haemoglobin level of the subject. 2. Pregnant/lactating women 3. Subjects who have taken antibiotics before the initiation of study 4. Subjects with a history of periodontal treatment in the last 6 months 5. Subjects with symptoms of acute illness, orthodontic appliances or presence of oral mucosal inflammatory conditions or salivary gland dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Initiation and progression of periodontal diseases is the result of a complex interaction between the bacteria colonizing the gingival crevice and the innate and inflammatory responses of the host.this study aims to closely investigate the relationship between GCF free haem concentration, subgingival microbial composition and periodontal clinical parameters in smokers and non-smokers and find out if GCF free haem could be used as a biomarker for periodontal diseases.Timepoint: 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| This will help us in identifying susceptible patients in large populations very easily and quickly as it is a chair side diagnostic test. It will also help us to identify active diseased sites, predict sites vulnerable for future breakdown and serve as surrogate end points for monitoring the effectiveness of therapy which may not be possible with conventional diagnostic aidsTimepoint: 2 points | — |
Countries
India
Contacts
Public ContactDr Shobha Krishna Subbaiah
THE OXFORD DENTAL COLLEGE AND HOSPITAL
Outcome results
None listed