A prospective study in adult patients with pituitary adenoma treated with radiotherapy excluding the hippocampal

A prospective study to evaluate the feasibility of hippocampal sparing intensity modulated radiotherapy in preserving neurocognitive functions in adult patients with pituitary adenoma.

Status

Active, not recruiting

Phases

Phase 3

Study type

Observational

Source

CTRI

Registry ID

CTRI/2018/11/016345

Enrollment

Registered

2018-11-15

Start date

Unknown

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G938- Other specified disorders of brain Health Condition 2: null- Patients above 18 years of age diagnosed with pituitary adenomas.

Interventions

Intervention1: Radiotherapy: All patients will be treated using linear accelerator machine (LA), Intensity Modulated Radiotherapy Technique (IMRT) to standard doses. All patients will be treated with

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients must provide study-specific informed consent prior to study enrolment 2.Indication for adjuvant /radical radiotherapy 3.Patients who are treated in TMH Mumbai / ACTREC Navi Mumbai 4.Age > 18years 5.Patients consenting for the study 6.Karnofsky Performance Score of > 70

Exclusion criteria

Exclusion criteria: 1. Prior history of irradiation to head & neck region 2. Contraindication to MR imaging such as implanted metal devices, severe claustrophobia etc 3. Acute medical illness requiring intensive medical care. 4. Any evidence of chronic / severe or uncontrolled medical illnesses 5. Patients with known major psychiatric illness, on antipsychotic medications and/or on electroconvulsive therapy.

Design outcomes

Primary

Measure	Time frame
1) To evaluate feasibility of hippocampal sparing Intensity Modulated Radiotherapy for preserving neurocognitive functions in adults with pituitary adenomas. 2) To evaluate radiotherapy dose constraints for hippocampus & its correlation with neurocognitive functions. Timepoint: After the completion of the study	—

Secondary

Measure	Time frame
1) To evaluate changes in hippocampal perfusion using 99mECD SPECT after hippocampal sparing intensity modulated radiotherapy & its correlation with neurocognitive functions. 2) To evaluate for any association between quality of life and doses received by different CNS structures Hippocampus, Hypothalamus, Cochlea, Optic nerve and optic chiasm. Timepoint: After the completion of the study	—

Countries

India

Contacts

Public ContactDr Jayant Sastri Goda

Tata Memorial Hospital

godajayantsastri@gmail.com02224177000

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026