To study the effect of transcranial direct current stimulation on urges to smoke tobacco among opioid dependent smokers.

A randomised single blind sham controlled trial to evaluate the effect of transcranial direct current stimulation (tDCS) on tobacco craving among opioid dependent smokers maintained on Buprenorphine

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/11/016339

Enrollment

Registered

2018-11-15

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F172- Nicotine dependence Health Condition 2: F112- Opioid dependence

Interventions

Intervention1: Active tDCS: HC tDCS machine will be used in the study. Each subject will receive 5 sessions of tDCS with 1 session per day. The parameters that will be used in the study are as follows

Eligibility

Inclusion criteria

Inclusion criteria: Right handed Patients maintained on Buprenorphine for more than or equal to 3 months Current daily users of Tobacco by smoking route (Defined as Daily use of beedis or cigarettes in the past 1 month) Nicotine dependence as per ICD 10 criteria Minimum duration of Tobacco smoking is more than or equal to 1 year Smoking more than or equal to 10 cigarettes or beedis or both per day Willing to give informed consent

Exclusion criteria

Exclusion criteria: Current smokeless tobacco users (defined as using smokeless tobacco in past 1 month) Currently undergoing tobacco cessation treatment (in past 1 month) Current use of Benzodiazepines, Heroin, Tramadol, Dextropropoxyphene as confirmed by Urine Casette test Current alcohol harmful use or dependence (as per ICD 10 criteria based on History) Current cannabis harmful use or dependence (as per ICD 10 criteria based on History) History of significant head injury, epilepsy, major psychiatric or neurological illness (Based on history) Presence of any metallic implants or devices or metalic rods or pacemakers, etc. (Based on history and physical examination) Inability to give consent (Due to Mental retardation / any illness )

Design outcomes

Primary

Measure	Time frame
1) Baseline tobacco craving by Brief Questionnaire of Smoking Urges (BQSU) 2) Cue induced tobacco craving by Visual Analog ScaleTimepoint: Before 1st session of tDCS After 1st session of tDCS After 5th session of tDCS	—

Secondary

Measure	Time frame
Number of beedi/cigarette consumed per dayTimepoint: Before 1st session of tDCS and After 5th session of tDCS	—

Countries

India

Contacts

Public ContactSonali Jhanjhee

AIIMS

sonali_arj@hotmail.com01126594997

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026