Health Condition 1: N859- Noninflammatory disorder of uterus, unspecified Health Condition 2: K638- Other specified diseases of intestine Health Condition 3: R103- Pain localized to other parts of lower abdomen
Conditions
Interventions
Intervention1: Dexmedetomidine infusion: Intravenous dexmedetomidine infusion in
loading dose of 0.6μg/kg over 10 min before induction Maintenance
infusion 0.4 μg/kg/hr throughout the surgery till
Sponsors
University College of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: ASA I/II patients scheduled for elective abdominal surgery under general anaesthesia requiring endotracheal intubation and epidural catheter insertion will be included
Exclusion criteria
Exclusion criteria: Laparoscopic abdominal surgery Contraindications to epidural administration like bleeding disorders, deranged coagulation profile, local site infection, neurological or spinal disease etc. History of psychiatric disorders. Obesity (BMI > 30 kg/m2) Patients on beta blockers or those who have been on continuous steroid therapy for > 5 days in the last one year. History of allergy to any of the drugs being used in the study. Known case of endocrine abnormalities, pheochromocytoma, carcinoid tumor etc. H/o present or past malignancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum cortisolTimepoint: Before induction, 30 min after surgical incision, at the time of extubation, 2 hr post-extubation, 24 hr after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood GlucoseTimepoint: Before induction, 30 min after surgical incision, at the time of extubation, 2 hr post-extubation, 24 hr after surgery;Blood UreaTimepoint: Before induction, 24 hr after surgery;Emergence characteristicsTimepoint: 2 min after extubation;Heart Rate, mean arterial pressureTimepoint: Baseline, after loading drug, just before and immediately after tracheal intubation, at the time of surgical incision, every 10 min for the first 30 min and then every 30 min till completion of surgery, after skin wound closure, at the time of extubation and every 30 min post-operatively till 120 min. | — |
Countries
India
Contacts
Public ContactDr Vishal Kamal
University College of Medical Sciences and GTB Hospital, Delhi
Outcome results
None listed