Health Condition 1: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Health Condition 2: E43- Unspecified severe protein-caloriemalnutrition
Conditions
Interventions
Intervention1: Modified half Strength low osmolarity WHO ORS: Single WHO ORS packet containing 75 meq/L of sodium will be dissolved in two liters of clean water
50 g sucrose and 22.5 mL of potassium syrup (containing 30 mmol/L) of potassium will be added. This modified half strength solution provide less sodium (37.5 mmol/L), more potassium (40 mmol/L) and ad
Sponsors
University College of Medical Sciences and Guru Teg Bahadur Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Children aged between 6 months -59 months, and classified as SAM according to WHO Criteria (weight for height = 3 episodes ina day
Exclusion criteria
Exclusion criteria: (i)Children with known secondary causes of SAM (e.g., Chronic renal disorders, Congenital heart diseases, cerebral palsy, Known HIV infection, Malabsorption, Celiac disease); (ii) Children presenting with acute events like shock, convulsions, congestive heart failure, coma.; (iii) Children in whom oral/nasogastric feeding not safe (e.g., bilious vomiting, surgical complications, severe respiratory distress requiring oxygen therapy)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare proportion of children with hyponatremia (Serum sodium 135 mEq/L) after 12 hours of rehydration in children with SAM suffering from diarrheaTimepoint: After 12 hours of rehydration. | — |
Secondary
| Measure | Time frame |
|---|---|
| a)Proportion of hypokalemia, hypoglycemia and hypernatremia b)Serum levels of sodium, potassium and glucose c)Percent weight gain (rehydration) d)Frequency of loose stool e)Amount of ORS solution intake after 12 hours of rehydration between two groups f)Duration of diarrhea Timepoint: All the parameters given above will be assessed initially at recruitment ( 0 hours ) and repeated at the end of intervention ( 12 hours ), after rehydration. point f) i.e. duration of diarrheal illness will be assessed at discharge. | — |
Countries
India
Contacts
Public ContactNeha Kumari
University college of medical sciences
Outcome results
None listed