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A study comparing efficacy of two drops in patients undergoing a laser for closed angles

0.1% Nepafenac vs 0.09% Bromfenac Eye Drops in Post Laser Peripheral Iridotomy Inflammation- A Randomised Controlled Study

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/10/016227
Enrollment
158
Registered
2018-10-31
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H400- Glaucoma suspect

Interventions

Intervention1: 0.09% Bromfenac eye drops , one drop 2 times a day for 14 days: Non steroidal anti-inflammatory drug Control Intervention1: 0.1% Nepafenac eye drops , one drop 3 times a day for 14 days

Sponsors

Aravind Eye Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Primary angle closure suspects 2)Primary angle closure not started in anti-glaucoma medications post laser peripheral iridotomy 3)Best corrected visual acuity of 6/12 or better

Exclusion criteria

Exclusion criteria: 1) Corneal pathology like dry eyes 2) Significant cataract which is obscuring undilated disc evaluation 3) PAC patients who are started on glaucoma medication before or immediately after LPI 4) PACG and Secondary angle closure glaucoma 5) History of any topical therapy including NSAIDâ??s within the past 30 days prior to LPI 6) Patient on systemic steroids or non-steroidal anti-inflammatory drugs 7) Any History of Laser or intraocular surgery 8) Pregnant or nursing mothers 9) Monocular patients 10) Any evidence of uveitis (old or new) 11) Patients with bleeding in the eye after the LPI

Design outcomes

Primary

MeasureTime frame
To compare the anterior chamber inflammation control between 0.1% Nepafenac eye drops and 0.09% Bromfenac eye dropsTimepoint: 2 weeks

Secondary

MeasureTime frame
1)To compare the comfort level of patients between the 0.1% Nepafenac and 0.09% Bromfenac groups by questionnaire (Glaucoma symptom scale questionnaire) 2) To assess any adverse reaction to the two drops in prescribed dosageTimepoint: 2 weeks

Countries

India

Contacts

Public ContactLavanya G S

Aravind eye hospital

venkatesh@pondy.aravind.org

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026