A clinical study to investigate the efficacy of infusion of dextrose containing fluid in decreasing nausea and vomiting in patients undergoing key hole gall bladder surgery.

Effect of perioperative intravenous administration of 5% dextrose and 0.9% saline on postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy-A Randomized Blinded Study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/10/016224

Enrollment

Registered

2018-10-31

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K806- Calculus of gallbladder and bile duct with cholecystitis Health Condition 2: K807- Calculus of gallbladder and bile duct without cholecystitis Health Condition 3: K801- Calculus of gallbladder with othercholecystitis Health Condition 4: K802- Calculus of gallbladder without cholecystitis Health Condition 5: K808- Other cholelithiasis

Interventions

Intervention1: 5% Dextrose Intravenous Solution: It will be administered intravenously at the rate of 100 ml/hr at the time the gall bladder is taken out till 250 ml of the solution is infused. Only o

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesilogists status I andII Informed and written consent to participate in the study

Exclusion criteria

Exclusion criteria: I. Patients with cardiovascular disease II. Patients with blood sugar > 160 mg/dL in the morning of surgery III. Patients with BMI >= 30 kg/m2 IV. Presence of Diabetes Mellitus V. Patients with preoperative predicted Apfel score of >= 3 VI. Patients with Gastro Oesophageal Reflex Disorder and disorder. VII. Patient receiving antiemetic and steroid in last 48 hour vii. Pregnant females viii Increased intracranial pressure ix. Vestibular dysfunction like Meneireâ??s disease x. Cancer patient on chemotherapy and opioid xi. Intraopertive requirement of fluid resuscitation, vasopressor/ionotrope, blood component therapy xii. Patients in whom the procedure is converted to open surgical technique xiii. Surgery duration > 2 hours

Design outcomes

Primary

Measure	Time frame
To compare the incidence of PONV between patients, undergoing laparoscopic cholecystectomy under general anaesthesia, who received peri-operative 5% dextrose intravenously and those receiving 0.9% salineTimepoint: within the first 24 hours postoperative period	—

Secondary

Measure	Time frame
To compare intra-operative heart rate, systolic, diastolic and mean blood pressure between the groups. Timepoint: Intraoperative period;To compare requirement of post operative rescue antiemetic treatment. Timepoint: within the first 24 hours postoperative period;To compare the effect of dextrose infusion on patients having different Apfel score. Timepoint: within the first 24 hours post operative period;To record any other observationsTimepoint: Within first 24 post hours operative period	—

Measure

Time frame

To compare intra-operative heart rate, systolic, diastolic and mean blood pressure between the groups. Timepoint: Intraoperative period;To compare requirement of post operative rescue antiemetic treatment. Timepoint: within the first 24 hours postoperative period;To compare the effect of dextrose infusion on patients having different Apfel score. Timepoint: within the first 24 hours post operative period;To record any other observationsTimepoint: Within first 24 post hours operative period

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Countries

India

Contacts

Public ContactDr Priyam Saikia

Gauhati Medical College and Hospital

saikia.priyam80@gmail.com9706067392

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026