Health Condition 1: F329- Major depressive disorder, singleepisode, unspecified
Conditions
Interventions
Intervention1: Theta Burst Stimulation (TBS): TBS refers to a rTMS (repetitive transcranial magnetic stimulation) protocol where pulses are applied in bursts of three, delivered at a frequency of 50 H
Sponsors
NIMHANS hospital
Dr Satish Girimaji
Dr Urvaksh Mehta
Eligibility
Inclusion criteria
Inclusion criteria: 1. 12-18 years of age, either gender 2. Moderate â?? Severe Depression (as per DSM 5) 3. In patients in department of child & adolescent psychiatry,NIMHANS 4. Parents willing to consent for the study
Exclusion criteria
Exclusion criteria: 1. Intracranial implants (cochlear implants, aneurysmal clips) 2. Acute emergencies like high suicidal risk and catatonia where ECT is considered as a first line treatment 3. Current/Past history / family history of epilepsy 4. Adolescents on Methylphenidate , Bupropion , Clozapine, Tricyclic antidepressants 5. Active Neurological illness / head injury 6. Autism spectrum disorder , Intellectual developmental disorder 7. Organic mood disorders 8. Chronic physical illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To measure Adverse effect of TMS using structured tool devised by Pascal Leone , Visual analogue scale , Neuropsychological tests and rate of discontinuationTimepoint: baseline , daily after TMS sessions , 1 week , 2 week , 3 month | — |
Secondary
| Measure | Time frame |
|---|---|
| acceptability of TBS as a treatment modality as measured by ratio of those who accept TMS as treatment modality to those who were offered sameTimepoint: 2 weeks;efficacy in terms of change in severity of depression over period of 12 weeks as measured by fall in CDRS-R scoresTimepoint: Baseline , 2 weeks , 3 months | — |
Countries
India
Contacts
Public ContactSiddhesh Shere
NIMHANS , Bangalore
Outcome results
None listed