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Comparing two techniques of providing pain relief in breast surgery patients

Comparison of preoperative PEC-2 block and Opioid based general anaesthesia for postoperative pain relief, PONV and cancer recurrence in patients undergoing modified radical mastectomy:a randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/10/016210
Enrollment
70
Registered
2018-10-30
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: PECS block,dexmedetomidine,ketamine combination: PECS block with 30ml 0.25% bupivacaine,dexmedetomidine infusion (1µg/kg for 10 mins then 0.5µg/kg/hr),ketamine 0.5mg/kg Control Interv

Sponsors

Dr Shagun Bhatia Shah
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Weight 45-80 kg ASA physical status I&II Patients undergoing elective Modified Radical Mastectomy for breast cancer

Exclusion criteria

Exclusion criteria: Patient refusal Local anaesthetic allergy Infection at the site of PECS block Tumour at the site of PECS block

Design outcomes

Primary

MeasureTime frame
Comparison of postoperative VAS Scores at various time points Timepoint: Immediately after reversal of GA 1 Hour postoperatively 2 hourspostoperatively 4 hours postoperatively 8 hours post operatively 24 hours post operatively—

Secondary

MeasureTime frame
VASTimepoint: 3 Months after surgery;Postoperative nausea and vomiting(PONV)Timepoint: Immediately after reversal of GA 1 Hour postoperatively 2 hourspostoperatively 4 hours postoperatively 8 hours post operatively 24 hours post operatively ;ConstipationTimepoint: 1 Hour postoperatively 2 hourspostoperatively 4 hours postoperatively 8 hours post operatively 24 hours post operatively;Time to discharge from surgical intensive care unit(SICU)Timepoint: At the time of discharge from SICU;Intraoperative fentanyl requirementTimepoint: At the end of surgery;Intraoperative sevoflurane consumption/uptakeTimepoint: At the end of surgery;Intraoperative dexmedetomidine consumptionTimepoint: At the end of surgery;Cancer recurrenceTimepoint: 5 years and 7 years post surgery—

Countries

India

Contacts

Public ContactDr Shagun Bhatia Shah

Rajiv Gandhi Cancer Institute and Research Centre

shah.shagun@rgcirc.org9891769779

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 9, 2026