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A study to compare two drugs (dexmedetomidine and nitroglcerine) used to decrease blood pressure during operation in a controlled manner while using a technology (near infrared spectroscopy) to measure oxygen saturation in brain

COMPARISON OF THE EFFECTS OF DEXMEDETOMIDINE AND NITROGLYCERIN ON CEREBRAL OXYGEN SATURATION USING NEAR INFRARED SPECTROSCOPY IN PATIENTS UNDERGOING CONTROLLED HYPOTENSIVE ANAESTHESIA

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/10/016206
Enrollment
82
Registered
2018-10-30
Start date
Unknown
Completion date
Unknown
Last updated
2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: M00-M99- Diseases of the musculoskeletal system and connective tissue

Interventions

Intervention1: Effects of dexmedetomidine and nitroglycerin on regional cerebral oxygen saturation during controlled hypotensive anesthesia using noninvasive near infrared spectroscopy for detection o

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists (ASA) physical status I and II and scheduled to undergo surgery in supine position with neutral head position, under general anaesthesia with controlled hypotension will be enrolled for this randomised non-inferiority trial.

Exclusion criteria

Exclusion criteria: Preexisting cerebral pathology, Cognitive disability, Carotid artery stenosis, Cardiac disease, Orthostatic hypotension, Sensitivity to study drugs.

Design outcomes

Primary

MeasureTime frame
To compare the occurrence of cerebral desaturation events caused by use of dexmedetomidine and nitroglycerin for controlled hypotensive anaesthesia.Timepoint: 30 minutes—

Secondary

MeasureTime frame
To compare the effects of dexmedetomidine and nitroglycerin on left and right regional cerebral oxygen saturation, haemodynamics (blood pressure and heart rate) and postoperative cognitive decline, when used for controlled hypotensive anaesthesia.Timepoint: MMSE score will be re-evaluated after 3 days to look for postoperative cognitive decline (POCD). Any decrease in score 2 points will be defined as POCD.—

Countries

India

Contacts

Public ContactKoteshwar J Rao

All India Institute of Medical Sciences,Jodhpur.

schhabra0209@gmail.com7340033034

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026