To check the efficiency of two different routes (into the vein and into the muscle) of a medicine that will reduce swelling, pain and improve mouth opening after wisdom tooth removal. The medicine is dexamethasone and it reduces signs of inflammation.

Evaluation of efficacy of intramuscular and intravenous dexamethasone in reducing post operative swelling, pain and trismus after surgical removal of lower impacted third molars - A randomised controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/10/016164

Enrollment

Registered

2018-10-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: IM Dexamethasone: Injection: IM Dexamethasone, surgical removal of lower impacted third molar, evaluation and comparison of post operative pain, swelling and trismus on first, third and

Eligibility

Inclusion criteria

Inclusion criteria: 1. Impacted mandibular third molars with Pell and Gregory classification Class II or III and Level B or C on the radiograph and Pederson difficulty index of Moderately Difficult (5-6). 2. Subjects would be healthy individuals, 18 years of age or older and with AHA score I. 3. Subjects who would not require any prophylactic antibiotics or analgesics. 4. Subjects who would be travelling within 10km radius of the hospital.

Exclusion criteria

Exclusion criteria: 1. Patients with signs of active infection (fever/pus discharge/palpable and painful lymph nodes). 2. Immunocompromised subjects. 3. Medically compromised subjects (ASA score II, III, IV, V) 4. History of allergy to the drug used. 5. Pregnancy or lactation. 6. Those who use other drugs during the observation period (anticoagulants/antiepileptics/steroids/antifungals/antibiotics/analgesics). 7. Those who refuse to take part in the study or come for regular follow up.

Design outcomes

Primary

Measure	Time frame
Facial measurement, mouth opening and pain level would be recorded pre operatively and swelling, pain and trismus would be measured on first, third and seventh postoperative days.Timepoint: Facial measurement, mouth opening and pain level would be recorded pre operatively and swelling, pain and trismus would be measured on first, third and seventh postoperative days.	—

Secondary

Measure	Time frame
Evaluation of patient comfort after surgical removal of wisdom toothTimepoint: Evaluation of patient comfort on first, third and seventh day after surgical removal of wisdom tooth	—

Countries

India

Contacts

Public ContactMehul Saha

Manipal College of Dental Sciences

abhaytaranathk@gmail.com9741157122

Outcome results