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Influence of treatment with vitamin B12 (with or without calcium) in diabetes patients who are deficient in blood vitamin B12 levels due to long-term metformin (a key drug for diabetes) use.

Effect of methylcobalamin with or without calcium supplementation on serum vitamin B12 levels in vitamin B12 deficient metformin-treated type 2 diabetes mellitus patients.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/10/016153
Enrollment
20
Registered
2018-10-25
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: methylcobalamin and calcium carbonate: methylcobalamin 1000 µg + calcium carbonate 1250 mg (containing 500 mg of elemental calcium) daily for 2 months Control Intervention1: methylcobal

Sponsors

Gerard Marshall Raj
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with type 2 diabetes mellitus On metformin therapy (=1000 mg/ day) atleast for the past 3 months and not exceeding 5 years

Exclusion criteria

Exclusion criteria: - Patients with renal and liver diseases - Pregnant and lactating women - Patients with type 1 diabetes mellitus - Patients on proton pump inhibitors, H2 blockers or antacids for the past 12 months - Patients on multivitamin or calcium supplementation for the past 3 months - Strict vegetarians

Design outcomes

Primary

MeasureTime frame
Mean relative change in serum vitamin B12 levelsTimepoint: At baseline and after 2 months—

Secondary

MeasureTime frame
NATimepoint: NA—

Countries

India

Contacts

Public ContactGerard Marshall Raj

Sri Venkateshwaraa Medical College Hospital & Research Centre (SVMCH & RC)

drgmr1111@gmail.com9245124616

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026