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To assess whether insulin like growth factor-1 helps in bone formation around dental implants in type 2 diabetic patients.

â??Assessment of osteoblastic activity around dental implants following placement of IGF-1 loaded sustained release microspheres in Type 2 diabetic patientsâ??- A double blinded study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/10/016124
Enrollment
10
Registered
2018-10-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: insulin like growth factor-1: to assess the efficacy of igf-1 in bone formation around dental implants in well controlled diabetic patients. Control Intervention1: placebo microspheres:

Sponsors

kapil r
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Type 2 diabetic patients categorized as well controlled. HbA1C less than 7.5. (American Diabetes Association Guidelines 2017) 2.No active intraoral or systemic disease. 3.Mandibular bilaterally edentulous posterior teeth with satisfactory healing after tooth loss. 4.Minimum height of available bone - 11.5mm in the edentulous site.

Exclusion criteria

Exclusion criteria: 1.Uncontrolled diabetic patients. 2.History of radiation therapy in the head and neck region. 3.Severe clenching or bruxism. 4.Smokers 5.Drug or alcohol abuse

Design outcomes

Primary

MeasureTime frame
The sites receiving igf-1 will have increased bone formation when compared to the site receiving placebo microspheres.Timepoint: Osseointegration around dental implants will be assessed at the 90th day after implant placement—

Secondary

MeasureTime frame
To check the activity of insulin like growth factor-1 on osseointegration. To assess and compare the bone healing between the control and test at two different time intervals.Timepoint: Osseointegration around dental implants will be assessed at 30th and 60th day after implant placement.—

Countries

India

Contacts

Public Contactkapil r

sri ramachandra university

prosthodontics07@gmail.com9710200200

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026