Health Condition 1: L400- Psoriasis vulgaris
Conditions
Interventions
Intervention1: methotrexate (upto 15mg), atorvastatin 20mg: methotrexate 7.5mg to 15mg - per oral route, weekly once for 6 months
+
atorvastatin 20mg per oral daily for 6 months
Control Intervention1:
Sponsors
SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTRE
Eligibility
Inclusion criteria
Inclusion criteria: Patients presenting to the in-patient and out-patient department of dermatology, SRM medical college hospital, Potheri With chronic plaque type psoriasis diagnosed clinically &histopathologically (wherever necessary) by a dermatologist Having PASI score > 12 Patients who are statin naïve
Exclusion criteria
Exclusion criteria: acute or chronic liver disease myopathies family history of hereditary muscular disorders (assessed by history, clinical examination, raised serum alanine aminotransferase and creatinine phophokinase thrice the upper limit) uncontrolled hypertension with known allergy to any of the treatment patients taking any drug that might interact with statins already taking statins impaired renal function or creatinine >2.0 mg/dl active infection or WBC > 10,000/cmm pregnant and lactating females females and males who did not complete their family
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| reduction in PASI score more than or equal to 50% from intial PASITimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| reduction in PASI score more than or equal to 75% from intial PASITimepoint: 9 months | — |
Countries
India
Contacts
Public ContactDHIVYA S
SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTRE
Outcome results
None listed