Health Condition 1: F840- Autistic disorder Health Condition 2: F809- Developmental disorder of speech and language, unspecified Health Condition 3: F70- Mild intellectual disabilities Health Condition 4: F71- Moderate intellectual disabilities Health Condition 5: F808- Other developmental disorders of speech and language Health Condition 6: F88- Other disorders of psychological development Health Condition 7: F78- Other intellectual disabilities Health Condition 8: F848- Other pervasive develop
Conditions
Interventions
None listed
Sponsors
National Institutes of Health
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria includes subjects with neurodevelopment disorders. The study will not discriminate on the basis of race, sex, or religion. We anticipate males and females will be enrolled in roughly equal numbers.
Exclusion criteria
Exclusion criteria: Subjects with a recognizable genetic syndrome or with an evidence of a non-genetic factor contributing to NDD would be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This proposal would result in identifying genetic etiology for a spectrum of neurodevelopmental disorders by the application of CMA and WES technologies. Genetic diagnoses can lead to therapeutic interventions that improve the quality of life and provide options for carrier and prenatal testing with power to reduce the disease burden.Timepoint: 5 years | — |
Secondary
| Measure | Time frame |
|---|---|
| The international educational exchange will develop experienced personnel for this project, and shape national standards for genetic testing, management of genomic information in India.Finally, our resource investment in a populations-specific database and sample biorepository are the foundation for future studies to uncover novel genetic mechanisms of NDDs â?? both within and outside the exome and explore their impact on normal brain development and pathophysiology.Timepoint: 5 years | — |
Countries
India
Contacts
Public ContactDr Anju Shukla
Kasturba Medical College and Hospital, Manipal
Outcome results
None listed