FindTrial
Sign In

To assess exercise testing as a predictor of outcome after chemotherapy and surgery in patients of esophagus cancer.

Cardiopulmonary exercise testing as a predictor of postoperative outcome in patients undergoing esophageal cancer surgery following neoadjuvant chemotherapy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2018/10/016056
Enrollment
30
Registered
2018-10-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-D49- Neoplasms

Interventions

None listed

Sponsors

AIIMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18-75 years 2. ASA I and II 3. All patients of esophagus cancer (squamous cell carcinoma or adenocarcinoma) of the middle or lower third of esophagus, undergoing neoadjuvant chemotherapy followed by transthoracic McEwans or Ivor lewis esophagectomy. 4. Patients giving written informed consent

Exclusion criteria

Exclusion criteria: 1. Contraindications to perform CPET a. Unstable cardiac status (Acute myocardial infarction 3â??5 days, unstable angina, moderate stenotic valvular heart disease, uncontrolled arrhythmias, syncope, active endocarditis, acute myocarditis or pericarditis, hypertrophic cardiomyopathy, uncontrolled heart failure) b. Significant pulmonary hypertension c. Acute pulmonary embolus or pulmonary infarction d. Electrolyte abnormalities e. Thrombosis of lower extremities f. Orthopedic impairment that compromises exercise performance g. Uncontrolled asthma h. Pulmonary oedema i. Room air desaturation at rest j. Respiratory failure k. Acute noncardiopulmonary disorder that may affect exercise performance or be aggravated by exercise(i.e. infection, renal failure, thyrotoxicosis) l. Mental impairment leading to inability to cooperate 2. Pregnant patients 3. Emergency surgery

Design outcomes

Primary

MeasureTime frame
1. To Study the correlation between CPET variables and post operative morbidity in patients with esophagus cancer undergoing neo-adjuvant chemotherapy followed by surgery.Timepoint: post operative morbidity survery (POMS) to be done on day 3, 5, 7 postop—

Secondary

MeasureTime frame
1. To compare pre-chemotherapy and post chemotherapy CPET variables and their association with post operative outcome. 2. To look for association between CPET variables and length of hospital stay. 3. To look for association between CPET variables and 30 day mortality. Timepoint: mortality at 30 days—

Countries

India

Contacts

Public ContactAditi Suri

AIIMS, New Delhi

seemamishra2003@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026