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A study to assess the effectiveness of using high volume ventilation (12-15 mL/kg) in a case of cervical spine injury patients requiring mechanical ventilation, assessed in terms of getting off the ventilatory support as early as possible with fewer complications during the course of ICU stay.

A prospective randomized controlled trial to study the effect of high versus low tidal volume ventilation on the time to wean patients from ventilator having cervical spine injury(C1-C5)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/10/016028
Enrollment
56
Registered
2018-10-15
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S142- Injury of nerve root of cervical spine

Interventions

Intervention1: high tidal volume (12-15mL/kg): In post traumatic cervical spine injury patients requiring mechanical ventilation, intervention group will receive high tidal volume Control Intervention

Sponsors

Department of Neuroanaesthesiology
Lead Sponsor
Dr Ashish Bindra
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. Neurological level of injury C1-C5 2. Date of injury within 3 months of admission in ICU

Exclusion criteria

Exclusion criteria: 1.Any head injury- mild, moderate or severe 2.Chest wall injury 3.Past history of COPD, CHF, ASTHMA, OSA, VAP, ARDS

Design outcomes

Primary

MeasureTime frame
To determine if high tidal volume ventilation strategy facilitates faster weaning from the ventilator compared to low tidal volume ventilation in patients with cervical spine injury (C1-C5)Timepoint: 30 days or till weaning from ventilator is achieved, whichever is earlier—

Secondary

MeasureTime frame
i. To determine the incidence of atelectasis in both groups. ii. To observe the hemodynamics in terms of mean arterial pressure, heart rate and requirement of inotropic support in both groups. iii. To determine the incidence of ARDS in both groups iv. To determine the incidence of ventilator associated pneumonia in both the groups.Timepoint: Each parameter will be assessed daily—

Countries

India

Contacts

Public ContactDr DEEP SENGUPTA

AIIMS, New Delhi

dr_ashi2208@yahoo.com8826417127

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026