Comparison of Intrathecal Dexmedetomidine and Fentanyl on Vital parameters, stress response and Post-operative pain in Laparoscopic cholecystecomy surgeries.

Comparative evaluation of Intrathecal Dexmedetomidine and Fentanyl for Hemodynamic stress response and Post-operative Analgesia in Laparoscopic Cholecystectomy.

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/10/016016

Enrollment

Registered

2018-10-15

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C260- Malignant neoplasm of intestinal tract, part unspecified

Interventions

Intervention1: Fentanyl: Intrathecal Fentanyl 50mcg to be used. Intervention2: Dexmedetomidine: Intrathecal Dexmedetomidine 10mcg to be used. Intervention3: Dexmedetomidine: Patients in this group wil

Eligibility

Inclusion criteria

Inclusion criteria: A total of 75 patients of ASA GI and ASA GII divided in to three groups of 25 each in Group 1 ,2 and 3 and Intrathecal Dexmedetomidine 10mcg, Fentanyl 5omcg and equal volume of Normal saline used in three groups respectively. The response is noted in different stages of surgery like pneumo-peritoneum creation, deflation, recovery and post-operative analgesia.

Exclusion criteria

Exclusion criteria: Coagulation abnormality Infection at the site of Injection Emergency surgery

Design outcomes

Primary

Measure	Time frame
Hemodynamic stress response to pneumo-peritoneumTimepoint: At the end of surgery.	—

Secondary

Measure	Time frame
Postoperative analgesiaTimepoint: Upto 24 hours after end of surgery	—

Countries

India

Contacts

Public ContactProfJNirmala

Nizams Institute Of Medical Sciences, Hyderabad

njonnavithula@gmail.com9849422749

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026