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Effect of painkiller, piroxicam, on the success of local anesthesia during root canal treatment

Efficacy of piroxicam buccal infiltration and inferior alveolar nerve block in patients with ireversible pulpitis: a prospective double-blind, randomized clinical trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/10/016010
Enrollment
52
Registered
2018-10-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Piroxicam: NSAID, Oxicam Derivative, Dose: 1ml of 40mg per 2ml. Parentral route (Buccal Infiltration) Single Dose, before starting root canal treatment Control Intervention1: Normal Sal

Sponsors

RAMA DENTAL COLLEGE HOSPITAL AND RESEARCH CENTRE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Irreversible pulpitis of mandibular first molar teeth 2.vital teeth with no previous history of root canal treatment 3.teeth which will not have any periapical pathology.

Exclusion criteria

Exclusion criteria: 1.Known hypersensitivity to piroxicam. 2.Pregnancy or lactation. 3.Patients who have asthma or allergy to other anti-inflammatory drugs. 4.History of peptic ulcer. 5.Patients who are of less than 14 years. 6.Patients who have bleeding problems or are under anticoagulant therapy. 7.Patients with renal or liver disorders. 8.Patients with history of known or suspected drug abuse. 9.Patients who will take NSAIDs or antidepressants or sedatives within 24 hours before root canal treatment.

Design outcomes

Primary

MeasureTime frame
Success of Inferior Alveolar Nerve BlockTimepoint: 5 minutes, 10 minutes, 15 minutes

Secondary

MeasureTime frame
absence of pain during the caries and dentin removal , access cavity preparation and canal length measurements.Timepoint: 15 minutes

Countries

India

Contacts

Public ContactSaurav Paul

Rama Dental College, Kanpur

nandamuri_sridevi@yahoo.in8887856069

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026