Delaying clamping of the umbilical cord at birth and its beneficial effect on blood pressure in premature newborns.

Delayed cord clamping and its effect on hemodynamic instability in preterm neonates below 32 weeks

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/10/015991

Enrollment

Registered

2018-10-10

Start date

Unknown

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P298- Other cardiovascular disorders originating in the perinatal period

Interventions

Intervention1: Delaying clamping of the umbilical cord: Delaying clamping of the umbilical cord for a minimum duration of 40 seconds to a maximum duration of 2 minutes. Dose: Approximately 30 ml/kg of

Eligibility

Inclusion criteria

Inclusion criteria: Preterm neonates between 25 weeks to 31 weeks 6 days period of gestation delivered by normal vaginal route or by lower segment caesarian section in whom clamping of the umbilical cord is delayed by 40 seconds to 2 minutes would be included. All neonates in whom delayed cord clamping could not be followed for maternal or neonatal reasons would serve as the control population.

Exclusion criteria

Exclusion criteria: Preterm neonate with an antenatally diagnosed congenital anomaly including congenital cardiac lesions, aneuploidy, craniofacial dysmorphism, fetal bradycardia, severe intrauterine growth restricted (IUGR) neonate, Rh incompatibility or other causes of fetal anemia would be excluded.

Design outcomes

Primary

Measure	Time frame
To determine the incidence of hemodynamic instability in preterm neonates below 32 weeks gestational age admitted to the NICU Timepoint: From the time of birth and admission to the neonatal intensive care unit (NICU) to the completion of 48 hours of postnatal age	—

Secondary

Measure	Time frame
a. Requirement for PRBC transfusion before discharge b. Hemodynamically significant patent ductus arteriosus (HS-PDA) necessitating pharmacologic closure c. Incidence of retinopathy of prematurity (ROP) d. Late onset sepsis (LOS) e. Necrotizing enterocolitis (NEC) Stage 2 or greater f. Mortality Timepoint: From the time of birth and admission to the neonatal intensive care unit (NICU) to the time of discharge to home	—

Measure

Time frame

a. Requirement for PRBC transfusion before discharge b. Hemodynamically significant patent ductus arteriosus (HS-PDA) necessitating pharmacologic closure c. Incidence of retinopathy of prematurity (ROP) d. Late onset sepsis (LOS) e. Necrotizing enterocolitis (NEC) Stage 2 or greater f. Mortality Timepoint: From the time of birth and admission to the neonatal intensive care unit (NICU) to the time of discharge to home

—

Countries

India

Contacts

Public ContactVishal Vishnu Tewari

Armed Forces Medical College, Pune

docvvt_13@hotmail.com8826118889

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026