Health Condition 1: null- Adult patients admitted to the medical intensive care unit
Conditions
Interventions
Intervention1: Low dose risperidone: Syrup Risperidone 1mg per orally twice daily for the duration of ICU stay
Control Intervention1: Placebo: Identical syrup 1ml twice daily per orally for the durati
Sponsors
Christian Medical College Vellore
Eligibility
Inclusion criteria
Inclusion criteria: Patients admitted to the medical intensive care unit
Exclusion criteria
Exclusion criteria: No informed consent obtained Neurological disease(including post-cardiac arrest patients) Come due to drug overdose Alcohol withdrawal Antipsychotic therapy in the last 30 days Pregnancy or breast feeding Documented delirium prior to IUD admission Difficulty in CAM ICU assessment (serious auditory or visual disorders, mentally disabled) Expected ICU stay less than 1day Moribund and not expected to survive 2 days Known risperidone allergy Severe hemodynamic instability requiring vasopressors more the 20mcg/min Renal failure eGFR less than 30ml/min Liver failure child Pugh B/C
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium in the study patients as assessed by the CAM-ICU scoreTimepoint: During ICU stay | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of ICU stay Duration of hospital stay Mortality at 28 daysTimepoint: Follow up till 28 days | — |
Countries
India
Contacts
Public ContactAmita Jacob
CMC, vellore
Outcome results
None listed