Health Condition 1: G910- Communicating hydrocephalus Health Condition 2: G10-G14- Systemic atrophies primarily affecting the central nervous system
Conditions
Interventions
None listed
Sponsors
DEPARTMENT OF RADIODIAGNOSIS
Eligibility
Inclusion criteria
Inclusion criteria: CONTROLS: Volunteers referred for MRI for indications other than conditions causing increased or decreased intracranial pressures with age ranging from 18 to 80 years. Participants are recruited after the routine MRI/CT study shows suspicion or indeterminate results (i.e. discrepancy with clinical findings) and are then taken up for few special flow MRI sequences which require extra 12 minutes (apart from the routine protocol). The informed consent is taken at the MRI console. Enrolment in NPH group: Patients with clinical and imaging features of NPH and/or a positive tap test. Enrolment in diffuse cerebral atrophy group: Patients with imaging features typical of cerebral atrophy with no clinical or imaging features suggestive of NPH. Enrolment in hydrocephalus group: Patients with hydrocephalus caused by periaqueductal or fourth ventricular obstruction as seen on conventional CT/MR. Enrolment in benign intracranial hypertension group: Patients presenting only with papilledema with normal MR imaging. Enrolment of patients with clinical conditions resulting in CSF hypovolemia: True hypovolemic state CSF shunt over drainage Traumatic CSF leaks Iatrogenic CSF leaks (post dural puncture/post-surgical leaks) Spontaneous CSF leaks. With routine MRI or clinical follow-up suggesting CSF hypovolemia.
Exclusion criteria
Exclusion criteria: 1) Individuals with metallic implants in-situ. 2) Individuals with claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cut-off values for absolute stroke volume, net aqueductal stroke volume, mean velocity, maximum velocity, minimum velocity will be obtained for the sample population and the variations in these parameters in various disease states from the controls will be assessed concluding the extent of CSF hydrodynamics alterations.Timepoint: ZERO | — |
Secondary
| Measure | Time frame |
|---|---|
| To establish importance of MRI CSF flow study as an adjunct to conventional MRI in diagnosis of cases with increased and decreased intracranial pressure.Timepoint: ZERO | — |
Countries
India
Contacts
Public ContactVASUDHA AGARWAL
DEPARTMENT OF RADIODIAGNOSIS AND IMAGING
Outcome results
None listed