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Comparison of two separate dose of Melatonin as a drug used before anesthesia in cancer patient.

A Comparative Study of Two dose of Melatonin as Oral Premedication in Oncoanaesthesia; A Randomized Single Blind Control Study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/10/015917
Enrollment
90
Registered
2018-10-05
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C50-C50- Malignant neoplasms of breast Health Condition 2: C15-C26- Malignant neoplasms of digestive organs Health Condition 3: C51-C58- Malignant neoplasms of female genital organs Health Condition 4: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx Health Condition 5: C73-C75- Malignant neoplasms of thyroid and other endocrine glands Health Condition 6: C64-C68- Malignant neoplasms of urinary tract Health Condition 7: C43-C44- Melanoma and other malignant neopla

Interventions

Intervention1: Melatonin: 0.3mg/kg Per orally Stat dose 90min prior to anesthesia Intervention2: Melatonin: 0.5mg/kg Per orally Stat dose 90min prior to anesthesia Control Intervention1: Placebo: 90mi

Sponsors

Department of Anesthesiology kidwai Cancer Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: • Patients belonging to ASA physical status Grade I and Grade II. • Patients consenting for study.

Exclusion criteria

Exclusion criteria: Refusal, chronic HTN,severe cardiac disease, DM,hepatorenal impairment, psychiatric illness, Asthma, drugs like antiHTN, antipsychotics, antiepileptics. History of allergy to drug.emergency surgery, sleep disorder, obesity,difficult airway

Design outcomes

Primary

MeasureTime frame
SEDATION-RAMSAY SEDATION SCALE ANXIETY- VISUAL ANALOGUE SCALE ORIENTATION-O LOG SCALE PSYCHOMOTOR FUNCTION-LETTER CANCELLATION TEST, TRIEGER DOT TESTTimepoint: 90 MINUTES PRIOR TO SURGERY JUST BEFORE SURGERY—

Secondary

MeasureTime frame
HEMODYNAMIC RESPONSE TO INTUBATIONTimepoint: IMMEDIATELY AFTER INTUBATION, AND 5, 10, 15MINUTES AFTER IT—

Countries

India

Contacts

Public ContactRAVIKIRAN H M

Kidwai Cancer Institute

namrang@gmail.com9880642830

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026