To prevent discomfort and swelling in neck region after operation under general anaesthesia, inhalation of drug ketamine and ketamine combined with clonidine is given before giving anaesthesia.

Comparision of nebulized Ketamine and Ketamine with Clonidine in postoperative sore throat

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/10/015915

Enrollment

100

Registered

2018-10-05

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J398- Other specified diseases of upperrespiratory tract

Interventions

Intervention1: Nebulization preintubation: Nebulization preintubation once with ketamine 50 mg plus 3 ml normal saline for 15 mins and compared with ketamine 50 mg plus clonidine 150 mcg plus 2 ml nor

Eligibility

Inclusion criteria

Inclusion criteria: 1)physical status ASA 1-2 2)surgery in supine position under general anaesthesia lasting for up to two hours

Exclusion criteria

Exclusion criteria: 1)history of prior sore throat 2)patients using steroids or NSAIDS 3)patient with COPD, Asthma 4)mallampati grade >2 5)patients with >2 attempts of intubation 6)pregnant women 7)patient and/or his/her acceptable representative not willing to provide their voluntary written informed consent for participation in the study

Design outcomes

Primary

Measure	Time frame
Postoperative sore throatTimepoint: Sore throat intensity recorded at 4hrs, 8hrs, 12hrs and 24hrs postoperatively	—

Secondary

Measure	Time frame
Blood pressure and oxygen saturationTimepoint: Blood pressure and oxygen saturation measured at 4hrs, 8hrs,12hrs and 24hrs postoperatively	—

Countries

India

Contacts

Public ContactDr Shashank Shekhar

Indira Gandhi Institute of Medical Sciences

sshekhar4u@yahoo.com8085934938

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026