A Study to compare topical therapy(DPCP) in alopecia areata versus oral steroids

RANDOMISED CONTROLLED TRIAL TO COMPARE THE EFFECTIVENESS AND SAFETY OF LOW DOSE DEXAMETHASONE PULSE VERSUS CONTACT SENSITISATION WITH DIPHENYLCYCLOPROPENONE IN STABLE/NON PROGRESSIVE ALOPECIA AREATA IN CHILDREN

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/10/015870

Enrollment

Registered

2018-10-01

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L639- Alopecia areata, unspecified

Interventions

Intervention1: Oral mini pulse corticosteroids- dexamethasone: 2.5 mg twice a week, PO Intervention2: DPCP- topical: once weekly application half head, after sensitisation with 2% DPCP starting with 0

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with severe non progressive alopecia areata with SALT score more than 40 and age less than 18 years.

Exclusion criteria

Exclusion criteria: 1. Progressive AA- new lesions(more than 5 patches) in last 3 months 2. Patients with severe hepatic, renal or other systemic disorder 3. Patients experiencing spontaneous regrowth of lost hair 4. Patients of known hypersensitivity to DPCP 5. Presence of any contraindication for corticosteroids 6. Parents/Patients not giving consent

Design outcomes

Primary

Measure	Time frame
1. Change in SALT score from baseline in both the groups. 2. Cosmetically acceptable hair regrowth or cosmetically unacceptable hair regrowth in both the groups Timepoint: o months, 1 month, 2 months, 3 months, 4 months, 5 months, and at 6 months	—

Secondary

Measure	Time frame
Number of adverse effects in group A versus group BTimepoint: 24weeks	—

Countries

India

Contacts

Public ContactRahul Mahajan

Department of Dermatology, Venereology and Leprology PGIMER Chandigarh

drrahulpgi@yahoo.com01722756562

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026