Health Condition 1: L088- Other specified local infections of the skin and subcutaneous tissue
Conditions
Interventions
Intervention1: 1. Itraconazole daily
2. Terbinafine daily and itraconazole daily
3. Terbinafine daily and itraconazole pulse: 1. Itraconazole 5 mg /kg/day
2. Terbinafine 6 mg/kg/day and itraconazole 5
Sponsors
Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Clinically suspected tinea corporis, tinea cruris or tinea faciei or any combination of these 2. Confirmation of tinea by KOH microscopy Both criteria should be met.
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Lactation 3. Presence of any other type of tinea e.g. onychomycosis 4. Another skin disease at the site of tinea 5. Inability to come for follow ups 6. Intake of terbinafine or itraconazole in last 1 month 7. History of drug reaction or allergy to terbinafine or itraconazole 8. Present history of liver, renal or ischemic heart disease 9. Patients on treatment with drugs that have interaction with terbinafine or itraconazole 10. Patients requiring antihistamines due to co-existing skin disease e.g. urticaria 11. Abnormal complete blood count (for hemoglobin value taken as abnormal will be Any one criteria will exclude the patient.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical and microscopic cure (i.e. complete clearance of lesions and negative KOH microscopy)Timepoint: 2 weeks, 4 weeks, 6 weeks, 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of itchingTimepoint: 2 weeks, 4 weeks, 6 weeks, 8 weeks | — |
Countries
India
Contacts
Public ContactRadhika Raheja
Institute of Medical Sciences, Banaras Hindu University
Outcome results
None listed