Repairing your growing bone ends with your own cells.

Transplantation of autologous iliac crest physeal chondrocytes cultured in monolayer to treat Physeal bars in children

Status

Recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/09/015832

Enrollment

Registered

2018-09-25

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Limb deformity due to physeal damage caused by trauma or infection Health Condition 2: T758- Other specified effects of external causes

Interventions

Intervention1: cultured autologous chondrocytes transplantation harvested from the iliac crest in to physis defect : cartilage will be harvested from the iliac crest and the chondrocytes will be isola

Eligibility

Inclusion criteria

Inclusion criteria: The subject should Be of pediatric age group with a growth plate defect amenable to treatment Should have a definitive growth plate defect of 10 to 60% to on imaging MRI Should be Indian nationals and able to come for follow up regularly

Exclusion criteria

Exclusion criteria: Subjects with chronic illness. Subjects on long term medications. Subjects with active infection and inflammation on the growth plate. Subjects not suitable for surgery due to any other reasons. Subject unable to come for a minimum of 2 years follow up.

Design outcomes

Primary

Measure	Time frame
I. Primary outcome Integration of the transplant with the existing growth plate verified using radiograph. II. Secondary outcome The transplant gaining a synergistic function along with the growth plate leading to normal growth rate in the affected limb and prevention of anticipated complications such as physeal bars, limb shortening and angulations. The efficacy is measured by radiographs and clinical examinations Timepoint: 3 months, 6 months, 9 months(optional), 1 year, 18 months, 2 years	—

Measure

Time frame

I. Primary outcome Integration of the transplant with the existing growth plate verified using radiograph. II. Secondary outcome The transplant gaining a synergistic function along with the growth plate leading to normal growth rate in the affected limb and prevention of anticipated complications such as physeal bars, limb shortening and angulations. The efficacy is measured by radiographs and clinical examinations Timepoint: 3 months, 6 months, 9 months(optional), 1 year, 18 months, 2 years

—

Secondary

Measure	Time frame
premature closure or any other abnormality of growth plate Timepoint: 2 years	—

Countries

India

Contacts

Public ContactDr Vrisha Madhuri

Christian Medical College, Vellore

madhuriwalter@cmcvellore.ac.in09994516360

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026