Health Condition 1: M169- Osteoarthritis of hip, unspecified Health Condition 2: M161- Unilateral primary osteoarthritisof hip Health Condition 3: S729- Unspecified fracture of femur Health Condition 4: S829- Unspecified fracture of lower leg
Conditions
Interventions
Control Intervention1: Bupivacaine: Bupivacaine is a highly lipophilic amide compound which is commonly prepared as a racemic mixture of R(+) and S(-) isomers. However, it is associated with side effe
Sponsors
DR Ram Manohar Lohia Institute Of Medical Sciences
DR Ram Manohar Lohia Institute Of Medical Science
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with ASA physical status I-II 2. Age 18-65 years of either sex 3. Elective lower limb orthopaedic surgeries
Exclusion criteria
Exclusion criteria: 1. Patient refusal to give consent. 2. Patients with hypersensitivity to amide local anesthetics. 3. Pregnant patients. 4. Patients having raised ICP, neurological or neuromuscular diseases. 5. Patients with congenital spinal anomalies, scoliosis, post-traumatic vertebral injuries. 8. Patients with cardiovascular diseases, severe renal diseases, hepatic diseases or respiratory diseases. 9. Patients with severe hypovolaemia, hemorrhagic and hypovolemic shock, severe anemia, bleeding coagulopathy and Systemic or local infection. 10. Patients either on antiarrhythmic drugs or any other drugs which are known to cause alteration in myocardial conduction system.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in PR, QT, QTc intervalTimepoint: before induction,every 10 minutes after epidural loading for 1 hour then every 30 minutes till completion of surgery then every 4hourly for 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| change in heart rate and blood pressureTimepoint: before induction,every 10 minutes after epidural loading for 1 hour then every 30 minutes till completion of surgery then every 4hourly for 24 hours | — |
Countries
India
Contacts
Public ContactVaishali Agrawal
DR.Ram Mnohar Lohia Institute
Outcome results
None listed