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Influence of photodynamic therapy (diode laser) as an adjunct to scaling and root planing on the levels of Gingival Crevicular Fluid (GCF) Interleukin-6, 8 & 10 in the treatment of chronic periodontitis.

Effect of Photodynamic Therapy as an adjunct to Non-Surgical Periodontal Therapy on Gingival Crevicular Fluid (GCF) Interleukin-6, Interleukin-8 & Interleukin-10 Levels in Chronic Periodontitis: A Randomized Controoled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/09/015737
Enrollment
20
Registered
2018-09-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: V00-Y99- External causes of morbidity

Interventions

Intervention1: Non surgical periodontal therapy and photodynamic therapy: Improvement in periodontal status i.e reduction in probing pocket depth and gain in clinical attachment level in chronic perio

Sponsors

None
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Gingival Index (GI) >1; Probing Depth (PD) > 5mm and Clinical Attachment Loss (CAL) > 3mm with alveolar bone loss affecting > 30% of the teeth as detected on radiograph at the time of initial diagnosis, based on the classification by American Academy of Periodontology, 1999.

Exclusion criteria

Exclusion criteria: 1. Patients with medical disorders such as cardiovascular or renal disease, etc. 2. Patients with recent history or presence of acute or chronic infection. 3. Individuals with history of tobacco chewing and smoking. 4. Pregnant and lactating females. 5. Patients with history of periodontal therapy or antibiotic treatment or any other anti-inflammatory medication within previous 6 months. 6. Patients with history of poorly controlled diabetes, liver diseases, malignancy, radiotherapy, or allergy to toluidine blue.

Design outcomes

Primary

MeasureTime frame
Improvement in GCF levels of Interleukin-6, Interleukin-8, and Interleukin-10 are evaluated in chronic periodontitis patients undergoing Non-Surgical Periodontal therapy along with Photodynamic therapy in 3 months.Timepoint: 3 months.

Secondary

MeasureTime frame
Improvement in periodontal status i.e reduction in probing pocket depth and gain in clinical attachment level in chronic periodontitis patients undergoing Non-Surgical Periodontal therapy along with Photodynamic therapy at 1 and 3 monthsTimepoint: 3 months

Countries

India

Contacts

Public ContactDr Abhay P Kolte

VSPM Dental College & Research Centre, Nagpur

drabhaypkolte@gmail.com9011071467

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026