A research study done to assess the effect of a drug called ketamine on brain function outcome in patients suffering from severe traumatic head injury

Effect of ketamine infusion as neuroprotective agent on neurological outcome in patients with severe traumatic brain injury: A randomized controlled pilot study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/09/015729

Enrollment

Registered

2018-09-17

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S062- Diffuse traumatic brain injury

Interventions

Intervention1: ketamine: Intravenous Ketamine infusion 50 mcg/kg/min/ for the time till ICP monitoring being done Control Intervention1: normal saline: normal saline intravenous infusion at the rate o

Eligibility

Inclusion criteria

Inclusion criteria: ASA (American Society of Anesthesiologist) grade I and II patients Severe traumatic brain injury Mechanically ventilated Intracranial pressure monitoring being done

Exclusion criteria

Exclusion criteria: Age (less than 18 years and greater than 49 years) glaucoma Life threatening multiple injuries Severe systemic disease ASA grade more than III

Design outcomes

Primary

Measure	Time frame
Neurological outcome as assessed by Glasgow Outcome Scale Timepoint: 3 months	—

Secondary

Measure	Time frame
Effect on Intracranial pressure, cerebral perfusion pressure and mean arterial pressureTimepoint: 1 hour	—

Countries

India

Contacts

Public ContactDr Sourav Burman

ALL INDIA INSTITUTE OF MEDICAL SCIENCES (AIIMS), New Delhi

drnirajaiims@gmail.com9013770806

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 5, 2026