Health Condition 1: J96-J99- Other diseases of the respiratory system
Conditions
Interventions
Intervention1: All patients will be randomised into two groups ( A and B group). Methylprednisolone will be given for patients in group A.: For group A pateints 2 mg/kg/day IV methylprednisolone will
Sponsors
Rainbow childrens hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1.All children between 1 month to 18 years of age, intubated for acute hypoxemic lung injury qualifying the criteria of pediatric ARDS (mild , moderate or severe) as per the PALICC definition (2016) shall be included in the study.
Exclusion criteria
Exclusion criteria: 1.Children on CPAP/NIV/HFNC. 2.Children already receiving glucocorticoids. 3.Children who have contra-indication for use of steroids (e.g. immunosuppressed, severe burns( >30% Burns), or gastrointestinal bleed within the past 1 month. 4.Parents refusing for steroids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of oxygenation status trends during the first 5 days( Pao2/fio2, OI, OSI, SF).Timepoint: First 5 days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Analysis of clinical outcome parameters like duration of mechanical ventilation, ventilator free days, mortality and morbidity. 2.Ventilator parameters (FiO2, Tidal volume, Compliance, plateau pressure ) 3.Need of sedation (cumulative dose of sedatives, paralytics). Timepoint: Duration of hospital stay | — |
Countries
India
Contacts
Public ContactDr Farhan AR Shaikh
Rainbow Childrens Hospital
Outcome results
None listed