Health Condition 1: J960- Acute respiratory failure
Conditions
Interventions
Intervention1: High-flow oxygen therapy: Oxygen supply through a heated humidifier,Fisher & Paykel, with large-bore binasal cannula, with a gas flow rate of 60 liters per minute
Control Intervention1
Sponsors
Tata Memorial Center
Not Any
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age 18year and above 2.Respiratory rate of >25 breaths per minute 3.Ratio of the partial pressure of arterial oxygen (PaO2) to the fractional oxygen (FiO2) of 300 mm Hg or less while the patient breathing oxygen with oxygen analyzer in situ at a flow rate of 10 liters per minute for at least 15 minutes
Exclusion criteria
Exclusion criteria: 1.The main exclusion criteria is PaCo2 >45 mm Hg, 2.Exacerbation of asthma or chronic respiratory failure, 3.Cardiogenic pulmonary edema, 4.A history of underlying chronic respiratory disease 5.Hemodynamic instability, use of vasopressors in a dose more than 0.25mcg/kg/min, 6.Glasgow Coma Scale score of 12 points or less 7.Contraindications to NIV 8.Urgent need for endotracheal intubation, 9.Palliative patients 10.Tracheostomy 11.Likelihood of Survival 12.Patient with respiratory failure due to potentially irreversible causes e.g. Post radiotherapy fibrosis, Progression of Lung diseases etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| No of patients that will require endotracheal intubationTimepoint: between day 1 to 28 days after randomization | — |
Secondary
| Measure | Time frame |
|---|---|
| 1 Number of ventilator free days (i.e., days alive and without invasive mechanical ventilation)Timepoint: between day 1 to day 28 after randomization;2 Mortality in the ICUTimepoint: at day 90 after randomization;3 Intubation rate in those with P/F ratios below 200Timepoint: between day 1 to day 28 after randomization;4 Intubation rate in neutropenic patientsTimepoint: between day 1 to day 28 after randomization;5 Total duration of ICU staysTimepoint: between day 1 to day 28 after randomization;6 Complication rates (e.g septic shock, nosocomial pneumonia, cardiac arrhythmia, and cardiac arrestTimepoint: between day 1 to day 28 after randomization;7 Grade of dyspneaTimepoint: between day 1 to day 28 after randomization | — |
Countries
India
Contacts
Public ContactDr Sheila Nainan Myatra
Tata Memorial Center
Outcome results
None listed