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Comparing the effect of chloroquine eye drops with olopatidine drops versus olopatidine eye drops alone in patients of allergic keratoconjunctivitis.

Comparative evaluation of combined 0.03% chloroquine phosphate with 0.1% olopatidine versus 0.1% olopatidine drops in cases of allergic keratoconjunctivitis.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/09/015679
Enrollment
200
Registered
2018-09-11
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Allergic keratoconjunctivitis Health Condition 2: H162- Keratoconjunctivitis

Interventions

Intervention1: Chloroquine phosphate: It is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. route of administration- topical (ocular) dose

Sponsors

FDC Limited
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients coming in the outpatient department with ocular itching, redness and watering and diagnosed as a case of seasonal allergic conjunctivitis on the basis of sign (hyperemia and papillaae) at slit lamp examination.

Exclusion criteria

Exclusion criteria: 1. Uveitis, conjunctivitis (due to other cause) and other ocular pathology. 2. Bronchial asthma, eczema. 3. History of dry eye, blepharitis, using contact lens. 4. Receiving topical or systemic medication. 5. History of hypersensitivity to any constituents of the eye drops.

Design outcomes

Primary

MeasureTime frame
Symptom control Timepoint: follow up 1week, 4 week, 8 week and 12 week.

Secondary

MeasureTime frame
1. decrease in tear osmolarity 2. decrease in Inflammtory markers MMP9 Alpha antitrypsin, Interleukin1, interleukin 8, interferon gamma levelTimepoint: before treatment and at last follow up

Countries

India

Contacts

Public ContactNamrata Sharma

Dr.R.P.Centre for Ophthalmic Sciences, AIIMS

namrata.sharma@gmail.com011-26593144

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026