Comparison of Effect of Adalimumab versus Hyaluronic Acid in Knee Osteoarthritis

A Randomized Controlled Trial to Compare the Effect of Intra -Articular Adalimumab Versus Intra - Articular Hyaluronic Acid in Primary Osteoarthritis of the Knee

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2018/09/015662

Enrollment

Registered

2018-09-08

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: null- Primary Osteoarthritis of the Knee

Interventions

Intervention1: Adalimumab: 10 mg of Ultrasound Guided Adalimumab + Quadriceps Strengthening Exercises + Hamstring Stretching Exercises + Joint Protection Techniques + ADL Modifications Control Interve

Eligibility

Inclusion criteria

Inclusion criteria: 1. Diagnosis of Knee OA as per 2016 ACR Revised Criteria for Early Diagnosis of Knee OA 2. Unilateral Primary OA of Grade 2 or Grade 3 on Kellgren Lawrence Scale 3. Pain Score >4 on VAS( Visual Analogue Scale) within the past one month 4. Lack of efficacy of previous treatment with Diclofenac at a dose of 75mg/day

Exclusion criteria

Exclusion criteria: 1. Previous treatment with TNF inhibitors 2. Previous Intra - Articular treatment within 3 months 3.Previous Knee Surgery 4. History of tumor or serious Infection 5. Pregnancy 6. Lactation 7. Cognitive Impairment 8. Previous history of trauma to the knee

Design outcomes

Primary

Measure	Time frame
To Compare the Effect of a Single Ultrasound - Guided Intra - Articular Injection of Adalirec) mumab with a Single Ultrasound Guided Intra -Articular Injection of Hyaluronic Acid on Pain using VASTimepoint: 4 weeks and 12 weeks post injection	—

Secondary

Measure	Time frame
To Compare the Effect of a Single Ultrasound - Guided Intra - Articular Injection of Adalimumab with a Single Ultrasound Guided Intra -Articular Injection of Hyaluronic Acid on Pain, other Symptoms, Function in Daily Living(ADL), Function in Sport and Recreation(Sport/Rec) using KOOS ScaleTimepoint: 4 weeks and 12 weeks post injection	—

Countries

India

Contacts

Public ContactDr Abhimanyu Vasudeva

AIIMS, New Delhi

slyaiims@yahoo.co.in9560678577

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026