Health Condition 1: G978- Other intraoperative and postprocedural complications and disorders of nervous system
Conditions
Interventions
Intervention1: dexmedetomidine for iv use: Preoperative intravenous infusion at 1mcg/kg (diluted in 20 ml saline) over 10 minutes before induction.
Intraoperative continuous intravenous infusion at 0.
Sponsors
institute of neurosciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. ASA-I and II scheduled for elective craniotomy 2. Either sex 3. Age group 18 to 70 years 4. Preop GCS 15/15 5. No neuropsychiatric illness, alcohol or drug abuse 6. Co-operative and able to give informed consent in person.
Exclusion criteria
Exclusion criteria: 1. ASA III and above 2. Age less than 18 years and more than 70 years 3. Preoperative GCS 4. Allergy to study drug 5. Severe respiratory, renal or hepatic disease 6. Psychiatric medical history 7. Severe hypotension (mean arterial pressure [MAP] 8. Patient requiring post-op mechanical ventilation (planned/unplanned)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| acute postoperative pain in the PACU using the numeric rating scale (NRS)Timepoint: postoperative | — |
Secondary
| Measure | Time frame |
|---|---|
| complications including hypertension (systolic blood pressure more than 20% of baseline value), tachycardia (HR more than 100 beats/min) and PONV.Timepoint: postoperative;first requirement of postoperative analgesic (paracetamol, tramadol)Timepoint: postoperative;intraoperative consumption of propofol and fentanyl,Timepoint: inraoperative | — |
Countries
India
Contacts
Public ContactDr Ardija singh
institute of Neurosciences, Kolkata
Outcome results
None listed