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Effect of Diode Laser as an additional therapy to Scaling and Root Planing on the levels of Gingival Crevicular Fluid (GCF) Endocan, Vascular Endothelial Growth Factor-A and Tumor Necrosis Factor-α in Aggressive Periodontitis.

Effect of Diode Laser as an adjunct to Non-Surgical Periodontal Therapy on Gingival Crevicular Fluid (GCF) Endocan, Vascular Endothelial Growth Factor-A and Tumor Necrosis Factor-α Levels in Aggressive Periodontitis: A Randomized Controlled Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2018/09/015583
Enrollment
20
Registered
2018-09-04
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Non-surgical Periodontal therapy and Diode Laser therapy: Improvement in periodontal status i.e reduction in probing pocket depth and gain in clinical attachment level will be evaluated

Sponsors

none
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients, aged Patients affected and diagnosed with moderate to severe aggressive periodontitis as assessed with GI >1; probing depth (PD) > 5mm and clinical attachment loss (CAL) > 3mm with alveolar bone loss affecting > 30% of the teeth as detected on radiograph at the time of initial diagnosis.

Exclusion criteria

Exclusion criteria: Patients with medical disorders like cardiovascular, renal disease, etc. Patients with recent history of acute or chronic infection. Individuals with history of tobacco chewing and smoking. Pregnant and lactating females. Patients with history of periodontal therapy or antibiotic &/or anti-inflammatory medication within previous 6 months.

Design outcomes

Primary

MeasureTime frame
Improvement in GCF Endocan, Vascular Endothelial Growth Factor (VEGF-A) and Tumor Necrosis Factor-α (TNF-α) levels in aggressive periodontitis patientsTimepoint: 3 months—

Secondary

MeasureTime frame
Improvement in periodontal status i.e reduction in probing pocket depth and gain in clinical attachment level in aggressive periodontitis patientsTimepoint: 1 and 3 months—

Countries

India

Contacts

Public ContactDr Abhay P Kolte
drabhaypkolte@gmail.com9011071467

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026